A deep-learning model trained on human data reveals that promoter mutations may explain a significant portion of unsolved ...

DNA enhancers, crucial for gene regulation, can be distant from the genes they control, requiring 3D looping to interact with promoters. A shared genetic mechanism appears to regulate both ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can offer new treatment opportunities.

Two promoter regions "face" each other, both of which initiate transcription. This so-called convergent transcription resembles a genomic ghost ride and was long considered an obstacle to gene ...

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a ...

Decoding plant gene expression: A deep dive into promoters and terminators for advanced bioengineering. In high-precision bioengineering and synthetic biology, the fine-tuning of gene expression ...

Characterizing gene promoters and promoter–terminator combinations is crucial for maximizing the benefits of bioengineering applications in plants. However, traditional methods of identifying ...

The U.S. FDA has granted orphan drug designation to Klotho Neurosciences Inc.’s secreted-Klotho (s-KL) promoter, gene and ...

In head-to-head comparisons, the new promoters outperformed the widely used GRK1 promoter in both expression strength and specificity. “This study addresses one of the biggest hurdles in IRD treatment ...

DNA contains genetic material called promoters, which essentially switch genes on and off. Because DNA is twisted and coiled in a 3D shape, these promoters can control genes that are located far ...