Analysis of proteomic profiles of tumours and cell lines reveals that the abundance of a paralogous protein is often ...

establishing the world's largest protein sequence dataset and designing models based on this dataset, which enables targeted modification and selection of proteins with specific functionalities.

Over the last decade or so, new multiple sequence alignment methods have been developed to improve comparative analyses of protein structure, but these new methods have not been typically used in ...

Abstract: Smith-Waterman (S-W) algorithm is an optimal sequence alignment method and is widely used for genetic databases. This paper presents a Graphics Processing Units (GPUs) accelerated S-W ...

The shape of a protein is dictated by its amino acid sequence. While sequences may mutate, the overall structure often remains similar to preserve function. The researchers hypothesised they could ...

Protein molecules are formed from many individual units called amino acids, which are encoded by three "letter" DNA sequences. It should therefore be possible to predict the 3D structure of a ...

AlphaFold (Panel B) takes as input the 1D sequence of a protein of unknown structure and a multiple sequence alignment (MSA) of many similar proteins found in different species and tissues.

Each protein or peptide consists of a linear sequence of amino acids. The protein primary structure conventionally begins at the amino-terminal (N) end and continues until the carboxyl-terminal (C ...

Computational protein structure prediction has been significantly improved by the application of coevolution information derived from multiple sequence alignment (MSA) and deep learning. Although very ...

But proteins are well suited to these algorithms. Their primary sequences can be described by language models, and their 3D structures work with computer vision training and image generation.

“The amount of amino acid sequences that we know is very high and growing; however, little is known about the properties of the proteins corresponding to these sequences. Fortunately, deep ...