Lipid kinases are enzymes that play a critical role in both cell signaling and membrane trafficking by phosphorylating lipid ...

It blocks atypical activation of the MET receptor tyrosine kinase pathway that occurs because of mutations (such as exon 14 skipping alterations or other point mutations), gene amplification or ...

Expression of the Ret receptor tyrosine kinase is a defining feature of enteric neurons. Its importance is underscored by the effects of its mutation in Hirschsprung disease, leading to absence of gut ...

GlobalData’s report assesses the drugs in the ALK Tyrosine Kinase Receptor pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

New findings for PTPRK, a receptor tyrosine phosphatase linked to the regulation of cell–cell adhesion, growth factor signaling, and tumor suppression.

On February 5, 2024, a new research paper was published in Oncotarget, entitled, “Neurotrophic-tyrosine receptor kinase gene fusion in papillary thyroid cancer: A clinicogenomic biobank and ...

pYtags are novel biosensors that can be used to measure the activity of a receptor tyrosine kinase of interest in live cells with high spatiotemporal resolution and are applied to reveal rapid ...

Angiogenesis is a critical step in tumor growth, development, and invasion. Nascent tumor cells secrete vascular endothelial growth factor (VEGF) that significantly remodels the tumor microenvironment ...

Spleen tyrosine kinase (Syk) is an essential player in immunity through its ability to couple a variety of membrane immunoreceptors to intracellular signaling pathways in an immune response. Activated ...

Bruton tyrosine kinase (BTK) inhibitors are an emerging type of DMT for MS; many of these agents are being tested in clinical trials globally for relapsing, primary, and secondary progressive MS.