ROS production increases during M-CSF- or GM-CSF-induced macrophage differentiation from monocytes, and the antioxidant BHA specifically inhibits M2 and TAM polarization.

However, the inhibitory effect of ROS elimination on macrophage differentiation is overcome when cells are polarized to classically activated (M1), but not M2, macrophages.

Here, the team found that ROS levels in both bone marrow derived macrophages (BMDMs) and adipose tissue macrophages of TBC1D1 S231A mice were significantly higher than those of wild-type mice.

Although macrophages direct ROS against invading bacteria, Salmonella typhimurium, the microbe used in the study, is adept at evading these defenses.

However, ROS are also naturally produced by cells of the immune system, in particular by macrophages, in response to exposure to pathogens. Macrophages are, similar to dendritic cells, generated ...

Like neutrophils, macrophages were attracted to wounds by ROS and protein kinase signaling, and macrophages lacking the ROS-generating enzyme Nox2 were unable to migrate into wounds and induce the ...

Due to the extensive usage of nanoparticles, toxicologists and scientists alike are interested in better understanding their safety profile. The toxic effects of nanoparticles on macrophages, for ...

Researchers at the Icahn School of Medicine at Mount Sinai have designed a regenerative medicine therapy to speed up diabetic wound repair.