This paper aims to identify the current state of the art of the latest research related to Conjugate Gradient (CG) methods for unconstrained optimization through a systematic literature review ...

ASCO 2025 phase 1b/2 study assessing 9MW2821, nectin-4 antibody drug conjugate, toripalimab in treatment-naïve patients, locally advanced or metastatic urothelial carcinoma.

In-line optical phase conjugation is a well-known technique to enhance the received signal quality through nonlinearity compensation. Being able to implement the conjugation in cm-scale highly ...

TNP-2198, a stable conjugate of a rifamycin pharmacophore and a nitroimidazole pharmacophore, has been designed, synthesized, and evaluated as a novel dual-targeted antibacterial agent for the ...

This review is organized into six sections: (1) the progression from traditional modeling approaches to AI-driven design of individual ADC components; (2) the application of deep learning (DL) to ...

Implications for Global Health Equity Protein conjugate vaccines, which are already in use for diseases like Haemophilus influenzae and pneumococcus, are known for their safety, scalability, and ...

Transferrin receptor 1 (TfR1) is a ubiquitously expressed receptor characterized by rapid internalization kinetics and efficient receptor recycling, making it an attractive target for drug delivery.