Mechanistic discrepancies between species highlights the limitations of mouse models in advancing STING inhibition drugs for various diseases.

In 1977, the Nobel Prize in Physiology or Medicine was awarded to Roger Guillemin and Andrew Schally for their discovery and synthesis of ...

In 1977, the Nobel Prize in Physiology or Medicine was awarded to Roger Guillemin and Andrew Schally for their discovery and synthesis of gonadotropin-releasing hormone (GnRH), a key regulator of ...

For decades, experts in the nutrition space told athletes to stick to 20 to 25 grams of protein after training. The prevailing myth is false.

More information: Yunsik Kang et al, Structural basis of lipid transfer by a bridge-like lipid-transfer protein, Nature (2025). DOI: 10.1038/s41586-025-08918-y ...

Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Credit: Eric Smith Researchers at the University of Chicago ...

Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), proteins embedded in cell membranes that allow cells to communicate with ...

New research combines two powerful imaging techniques to study the complete structure of a common aGPCR, including how its long and complex extracellular region interacts with the transmembrane ...

Extracellular signals perceived by 7-transmembrane (7TM)-spanning receptors initiate desensitization that involves the removal of these receptors from the plasma membrane. Agonist binding often evokes ...

(45) The Gram-negative YidC protein possesses an additional transmembrane (TM) segment at the N-terminus and a large periplasmic domain (PD) region (Figure 1). (46,47) Although the PD region and the ...