In diseases due to exposure to toxic particles like gout, macrophages elicit separate pathways for inflammation and lysosomal ...

Suppression of metastasis-promoting microenvironment by blocking signaling pathway may be ... the PlGF/ VEGFR-1 pathway may be ... immunosuppressive tumor-associated macrophages.

Inhibiting the PIGF/VEGFR-1 signaling regressed tumor growth in obese, but not in lean mice, the author report. Obesity is a confirmed risk factor for the development of several cancers, including ...